Uveitis:

Uveitis is an inflammatory disease that produces swelling and loss of vision through the destruction of eye tissues. There is a significant need for improved treatment options as uveitis causes about 30,000 new cases of blindness each year in the United States alone.

Axial Spondyloarthritis:

Axial spondyloarthritis (AxSpA) is an inflammatory musculoskeletal disease that mainly affects the spine, the pelvic joints, and the sites where ligaments and tendons attach to bones called “entheses”. It is estimated as many as 2.7 million adults in the United States have axial spondyloarthritis.

Hidradenitis Suppurativa:

Hidradenitis suppurativa (HS) is a very painful, lifelong, and recurring skin condition that causes abscesses and scarring. Areas often affected include the groin and genitals, the armpits, areas around the anus, and below the breasts. The exact cause of hidradenitis suppurativa is unknown although it is thought to affect 0.1%-2% of the population.

Psoriatic Arthritis:

Psoriatic arthritis (PsA) is a chronic, inflammatory disease that affects the joints, skin, nails, spine and sites where ligaments and tendons attach to bones called “entheses”. It is estimated that about 30% of psoriasis patients will develop psoriatic arthritis.

About Enthesitis:

Entheseal tissues anchor muscles to bone and bones to bone through tendons and ligaments. Given this role, enthesites have very high strength, are very dense tissues, and are poorly vascular, making penetration by large molecules like monoclonal antibodies difficult. It is estimated that 50-60% of patients with PsA experience enthesitis, which presents more frequently in more serious patients and is associated with increased disease activity, reduced quality of life and worse prognostic outcomes. Currently approved therapies demonstrate enthesitis resolution in approximately only 45-60% of patients.